Perfect Tools for Pristine Oligos

Guzaev, Andrei P; Vvedensky, Vladimir Y. Phosphoramidite building blocks for sugar-conjugated oligonucleotides. US 10,087,208

Guzaev, Andrei P. Sulfur transfer reagents for oligonucleotide synthesis. US 8,552,175

Ravikumar, Vasulinga; Manoharan, Muthiah; Guzaev, Andrei P.; Wang, Zhiwei; Kumar, Raju Krishna. Supports for oligomer synthesis.    US 8,541,599

Ravikumar, Vasulinga; Manoharan, Muthiah; Guzaev, Andrei P.; Wang, Zhiwei; Kumar, Raju Krishna. Supports for oligomer synthesis.    US 8,153,725

Guzaev, Andrei P. Sulfur transfer reagents for oligonucleotide synthesis. US 7,723,528

Ravikumar, Vasulinga; Manoharan, Muthiah; Guzaev, Andrei P.; Wang, Zhiwei; Kumar, Raju Krishna. Preparation of 5,6-dihydroxy-iso-indole derivatives as linkers for DNA solid phase synthesis. US Pat. Appl. Publ. (2005), 74 pp., Cont.-in-part of US. Ser. No. 770,226, US 2005208588 A1 2005/09/22

Guzaev, Andrei P.; Manoharan, Muthiah.  Preparation of oxa-bicyclic heptane universal support media for solid phase synthesis of oligodeoxyribonucleotides. U.S. Pat. Appl. Publ. (2004), 45 pp., Cont.-in-part of Appl. No. PCT/US03/23344, US  2004242897  A1 2004/12/02

Guzaev, Andrei P.; Manoharan, Muthiah.  Preparation of universal oxabicycloheptane building blocks and polymer support media for synthesis of oligonucleotides and their analogs.    U.S. Pat. Appl. Publ.  (2004), 57 pp., US  2004152905  A1 2004/08/05

Guzaev, Andrei P.; Manoharan, Muthiah. Preparation of oligodeoxyribonucleotides using phosphate and thiophosphate protecting groups. U.S. Pat. Appl. (2004), 49 pp., Cont.-in-part of U.S. 6,610,837, US 20040082774 A1 2004/04/29

Guzaev, Andrei P.; Manoharan, Muthiah; Ravikumar, Vasulinga T.; Kumar, Raju K. Preparation of universal polymer support media for solid phase synthesis of oligodeoxyribonucleotides. PCT Int. Appl. (2004), 118 pp. WO 2004011474 A1 2004/02/05

Manoharan, Muthiah; Guzaev, Andrei P.; Maier, Martin A. Polyalkyleneamine-containing oligomers for enhanced cellular uptake. U.S. Pat. Appl. Publ. (2004), 37 pp. US 2004019000 A1 20040129

Maier, Martin A.; Guzaev, Andrei P.; Manoharan, Muthiah. Method for sequential support-bound synthesis of conjugated oligomeric compounds. U.S. Pat. Appl. Publ. (2004), 38 pp. US  2004006203 A1 2004/01/08

Guzaev, Andrei P.; Manoharan, Muthiah. Preparation of universal polymer support media for solid phase synthesis of oligodeoxyribonucleotides. U.S. (2003), 33 pp. US 6653468 B1 2003/11/25

Guzaev, Andrei P.; Manoharan, Muthiah. Phosphate and thiophosphate protecting groups. U.S. (2003), 45 pp., Cont.-in-part of U.S. 6,121,437. US 6,610,837 B1

Guzaev, A. P.; Manoharan, M. Process for the synthesis of oligonucleotide compounds. US (2003), 24 pp., US 6,531,590 B1

Manoharan, Muthiah; Just, George; Guzaev, Andrei; Roland, Arlene; Wang, Jianchao; Jung, Michael E.. Oligonucleotides having alkylphosphonate linkages and methods for their preparation. U.S. (2002), 14 pp., US 6,486,313 B1

Manoharan, Muthiah; Guzaev, Andrei P. Process for preparing peptide-derivatized oligomeric compounds. U.S. Pat. Appl. Publ.  (2002), 45 pp., Cont.-in-part of U.S. Ser. No. 658,517. A1 20021024 CA 137: 279471

Manoharan, M.; Guzaev, A. Solid phase synthesis of cholesterol-linked and dye-labeled oligodeoxyribonucleotides. PCT Int. Appl. (2002), 111 pp. WO 0279216 A1 20021010

Manoharan, M.; Guzaev, A. Labeled oligonucleotides, methods for making same, and compounds useful therefor. PCT Int. Appl. (2002), 111 pp. WO 0279216 A1 20021010

Guzaev, A. P.; Manoharan, M. Solid phase synthesis of oligodeoxyribonucleotides. PCT Int. Appl. (2002), 92 pp. WO 0262811 A2 0020815. CA 137: 155148

Manoharan, M.; Guzaev, A. P. Process for preparing peptide-derivatized oligomeric compounds. PCT Int. Appl. (2002), 124 pp. WO 0220544 A1 20020314. CA 136: 63470

Guzaev, A. P.; Cook, P. Dan; Manoharan, M.; Bhat, B. Nucleosidic and non-nucleosidic folate conjugates. U.S. (2002), 88 pp., US 6,335,434 B1 20020101; Cont.-in-part of U. S. Ser. No. 98,166

Manoharan, M.; Guzaev, A. P. Labeled Oligonucleotides, methods for making same and compounds useful therefor. US patent application, (2001)

Guzaev, A. P.; Manoharan, M. Preparation of oligodeoxyribonucleotides using phosphate and thiophosphate protecting groups. U.S. (2000), 31 pp. US 6,121,437 A 20000919. CA 133: 222976

Ravikumar, V. T.; Manoharan, M.; Capaldi, D. C.; Krotz, A.; Cole, D. L.; Guzaev, A. Improved method for preparation of phosphate linked oligonucleotides with reduced formation of acrylonitrile-nucleic acid base adduct. Jpn. Kokai Tokkyo Koho (2000), 26 pp. JP 2000226399 A2 20000815; CA: 133:193420

Manoharan, M.; Just, G.; Guzaev, A.; Roland, A.; Wang, J.; Jung, M. E. Oligonucleotides having
alkylphosphonate linkages and methods for their preparation. PCT Int. Appl. (2000), 60 pp. WO 0049032 A1 20000824. CA 132:177412

Manoharan, M.; Bhat, B.; Cook, P. D.; Guzaev, A. P. Manoharan, Muthiah; Bhat, Balkrishen; Cook, Phillip Dan; Guzaev, Andrei P. Preparation of nucleosidic and non-nucleosidic oligodeoxyribonucleotide-folate conjugates. PCT Int. Appl. (1999), 207 pp. WO 9966063 A2 19991223; CA 132:50215

Manoharan, M.; Guzaev, A. Solid phase synthesis of triester oligonucleotides having bioreversible phosphate blocking groups. PCT Int. Appl. (1999), 61 pp., WO 9964434 A1 19991216; CA: 132:35995

Manoharan, M.; Gusaev, A. Synthesis of oligonucleotides having bio-reversible phosphate blocking groups. PCT Int. Appl. (1999), 79 pp., WO 9955717 A1 991104; CA: 131:31080

Ravikumar, V.; Manoharan, M.; Capaldi, D.C.; Krotz, A.; Cole, D.L. and Guzaev, A. Process for the synthesis of oligomeric compounds. US 6,465,628 B1

Manoharan, M.; Guzaev, A. Synthetic Methods and Intermediates for Triester Oligonucleotides. US Patent Application Ser. No. 09/095,822

Guzaev, A.; Azhayev, A.; Lonnberg, H. Preparation of phosphoramidites as phosphorylating agents in synthesis of oligodeoxyribonucleotides. Eur. Pat. Appl. (1998), 25 pp., EP 816368 A1 980107

Manoharan, M.; Guzaev, A. Processes for the Synthesis of Oligomeric Compounds. US Patent Application Ser. No. 09/066,638

Guzaev, A.; Azhayev, A.; Lönnberg, H. Chemical Phosphorylation of Oligonucleotides and Reactants Used Therefor. U.S. Patent 5,959,090

Galev, E. E; Guzaev, A. P.; Chernov, B. K.; Smirnov, O. Yu.; Abramov, V. M.; Zavyalov, V. P. Synthetic polynucleotides encoding the surface domains of CD4 antigen of human T-lymphocytes that bind glycoprotein gp120 of human immunodeficiency virus. Patent USSR SU 1761808, 15.09 1992 (in russian); CA 119: 47359q.

Chugunova, N. M.; Sterkhova, E. I.; Guzaev, A. P. Method of preparing N-isobutyryl-6-O-[2-(4-nitrophenyl)ethyl]-5'-O-dimethoxytrityl-2'-deoxyguanosine. Patent USSR  SU 1696433, 08.08. 1991 (in russian); CA 117: P49161b

Guzaev, A. P.; Surovtseva, V. M.; Surovtsev, V. I.; Kosarev, I. V.; Guzaeva, T. V.; Chugunov, A. M. A method to prepare an immunosorbent for the isolation of protein A from Staphilococcus Aureus. Patent USSR 1317911, 15.02. 1987 (in russian)

Guzaev, A. P.; Peretokin, A. V.; Cysek, E. Z.; Malina, Yu. F.; Unkovskii, B. V. Process for the synthesis of  alkyl substituted beta-chloroketones. Patent USSR 1074080, 15.10. 1983 (in russian)

Guzaev, A. P.; Jakover, L. L.; Malina, Yu. F.; Unkovskii, B. V. N-(3-Phenylallyl) benzamides. Patent USSR 1049474, 22.06. 1983 (in russian) CA 100: P138771s

Guzaev, A. P.; Malina, Yu. F.; Unkovskii, B. V. Process for the synthesis of 3-acylamino-1,3-diphenyl-1-propanones. Patent USSR 1014220, 21.12. 1982 (in russian)