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Unprotected Universal Solid Supports

Our advanced universal solid supports eliminate the need of using nucleosidic solid supports. Most oligonucleotides can be synthesized starting with a single universal solid support regardless of the desired 3′-terminal nucleoside. The unique design of our universal solid supports ensures an efficient synthesis (as measured by the purity and yield) of oligonucleotides.

Product Features

  • Compatibility with standard oligonucleotide synthesis protocols

  • Requires no special treatments or reaction conditions

  • Multiple ligand attachments (5’-end, 3’-end or at both the ends) to oligos

  • Used for small, medium, and large scale oligo synthesis

  • Synthesis of DNA, 2’-OMe (P=O and P=S backbones) oligos

  • Synthesis of RNA (P=O and P=S backbones) oligos

  • Numerous selections of universal solid supports* offered:

    • Solid phase material – CPG (500 Å, 1000 Å, 1400 Å, or 2000 Å), and Polystyrene

    • Succinyl (labile) or amide (stable) linker attachment to universal solid support

    • The state of the hydroxy group – unprotected (most user friendly)

  • Simplified inventory control

    • Single universal solid support versus several nucleosidic supports

  • Regulatory agency advantage – universal solid support deemed as raw material

  • Scientific publications demonstrating the robustness of universal solid supports

1. Guzaev, A. P. and Manoharan, M. A Conformationally Preorganized Universal Solid Support for Efficient Oligonucleotide Synthesis. 

J. Am. Chem. Soc. 2003, 125, 2380-2381

2. Kumar, R. K., Guzaev, A. P., Rentel, C., Ravikumar, V. T. Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides Using a Universal Solid Support. Tetrahedron 2006, 62, 4528-4534

* Under license from Ionis Pharmaceuticals

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