Unprotected Universal Solid Supports
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Our advanced universal solid supports eliminate the need of using nucleosidic solid supports. Most oligonucleotides can be synthesized starting with a single universal solid support regardless of the desired 3′-terminal nucleoside. The unique design of our universal solid supports ensures an efficient synthesis (as measured by the purity and yield) of oligonucleotides.
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Product Features
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Compatibility with standard oligonucleotide synthesis protocols
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Requires no special treatments or reaction conditions
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Multiple ligand attachments (5’-end, 3’-end or at both the ends) to oligos
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Used for small, medium, and large scale oligo synthesis
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Synthesis of DNA, 2’-OMe (P=O and P=S backbones) oligos
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Synthesis of RNA (P=O and P=S backbones) oligos
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Numerous selections of universal solid supports* offered:
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Solid phase material – CPG (500 Å, 1000 Å, 1400 Å, or 2000 Å), and Polystyrene
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Succinyl (labile) or amide (stable) linker attachment to universal solid support
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The state of the hydroxy group – unprotected (most user friendly)
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Simplified inventory control
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Single universal solid support versus several nucleosidic supports
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Regulatory agency advantage – universal solid support deemed as raw material
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Scientific publications demonstrating the robustness of universal solid supports
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1. Guzaev, A. P. and Manoharan, M. A Conformationally Preorganized Universal Solid Support for Efficient Oligonucleotide Synthesis.
J. Am. Chem. Soc. 2003, 125, 2380-2381
2. Kumar, R. K., Guzaev, A. P., Rentel, C., Ravikumar, V. T. Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides Using a Universal Solid Support. Tetrahedron 2006, 62, 4528-4534
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* Under license from Ionis Pharmaceuticals