Non-nucleosidic Modifier Phosphoramidites for Introducing Functional and Reporter Groups
AM Chemicals has designed* a novel family of non-nucleosidic phosphoramidites for introducing functional and reporter groups. The unique design of our non-nucleosidic phosphoramidites ensures an efficient synthesis (as measured by the purity and yield) of oligonucleotides.
Product Features
-
Novel, achiral non-nucleosidic building blocks (TMT-protected)
-
Amenable for single or multi-labeled oligo synthesis
-
Incorporation of the phosphoramidites at terminal or any desired position of the oligonucleotide
-
Compatible with standard oligonucleotide synthesis protocols
-
Free of structural motifs that lead to undesired side reactions at the deprotection step
-
Requires no special treatments or reaction conditions
-
Synthetically feasible for scale-up and manufacturing
-
Synthesis of DNA oligos with P=O and P=S backbones
-
Synthesis of RNA oligos with P=O and P=S backbones
-
Numerous other ligands are available upon customer’s request
-
Scientific publications** on the design, synthesis of non-nucleosidic phosphoramidites and preparation of ligand-oligonucleotides conjugates
** 1. Guzaev, A. P. Oral presentation delivered at XXII International Round Table, Paris, July 2016
2. Gogoi, K., Vvedensky, V., and Guzaev, A.P. Poster presented at TIDES 2017 Conference, San Diego, May 2017 (PDF)
* US Patent 10,781,175
-
Minimum order size (5 g)