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AM Chemicals

Sequential couplings yield trivalent GalNAc-oligo conjugate

1. Couple with GalNAc phosphoramidite, p/n 51210

2. Oxidation (X=O) or

Sulfurization (X=S) with p/n 30000

1. One more coupling cycle with

GalNAc phosphoramidite, p/n 51210

2. Assembly of the desired oligonucleotide;

3. Basic deprotection

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