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Sequential couplings yield trivalent GalNAc-oligo conjugate

1. Couple with GalNAc phosphoramidite, p/n 51210



2. Oxidation (X=O) or
Sulfurization (X=S) with p/n 30000

1. One more coupling cycle with
GalNAc phosphoramidite, p/n 51210
2. Assembly of the desired oligonucleotide;
3. Basic deprotection

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