Non-nucleosidic Modifier Solid Supports
for Targeted Cellular Uptake of Oligonucleotides
Non-nucleosidic Solid Support
GalNAc
CAS #: 2172953-35-2
[How to make 3 GalNAc cluster at 3'-end DEMO]
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612101 | CPG 500 | $150 | 45 umol/g |
612102 | CPG 1000 | $150 | 35 umol/g |
612103 | Polystyrene | $150 | 100 umol/g |
612104 | CPG 1400 | $150 | 30 umol/g |
612105 | CPG 2000 | $150 | 25 umol/g * |
612106 | CPG 3000 | $150 | 20 umol/g * |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
*Max loading as allowed by the available surface area
For a very similar compound and small amount requirements, please contact Glen Research
Non-nucleosidic Solid Support
Cholesteryl
CAS #: 2172953-39-6
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612301 | CPG 500 | $125 | 55 umol/g |
612302 | CPG 1000 | $125 | 50 umol/g |
612303 | Polystyrene | $125 | 100 umol/g |
612304 | CPG 1400 | $125 | 30 umol/g |
612305 | CPG 2000 | $125 | 25 umol/g * |
612306 | CPG 3000 | $125 | 20 umol/g * |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
*Max loading as allowed by the available surface area
Non-nucleosidic Solid Support
Tocopherol
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612311 | CPG 500 | $210 | 45 umol/g |
612312 | CPG 1000 | $210 | 35 umol/g |
612313 | Polystyrene | $210 | 100 umol/g |
612314 | CPG 1400 | $210 | 30 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612321 | CPG 500 | $125 | 45 umol/g |
612322 | CPG 1000 | $125 | 35 umol/g |
612323 | Polystyrene | $125 | 100 umol/g |
612324 | CPG 1400 | $125 | 30 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612331 | CPG 500 | $155 | 50 umol/g |
612332 | CPG 1000 | $155 | 35 umol/g |
612333 | Polystyrene | $155 | 100 umol/g |
612334 | CPG 1400 | $155 | 30 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612341 | CPG 500 | $155 | 50 umol/g |
612342 | CPG 1000 | $155 | 35 umol/g |
612343 | Polystyrene | $155 | 100 umol/g |
612344 | CPG 1400 | $155 | 30 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
Product Details
-
US Patent 10,781,175
-
Minimum order size (25 g)
-
For price info on package size of above 100g for all p/n, please inquire (info@amchemicals.com)
Product Features
-
Novel, achiral non-nucleosidic building blocks (TMT-protected)
-
Amenable for single or multi-labeled oligo synthesis
-
Incorporation of the phosphoramidites at terminal or any desired position of the oligonucleotide
-
Compatible with standard oligonucleotide synthesis protocols
-
Free of structural motifs that lead to undesired side reactions at the deprotection step
-
Requires no special treatments or reaction conditions
-
Synthetically feasible for scale-up and manufacturing
-
Synthesis of DNA oligos with P=O and P=S backbones
-
Synthesis of RNA oligos with P=O and P=S backbones
-
Numerous phosphoramidites and solid supports:
-
Solid phase material – CPG (500 Å, 1000 Å, or 1400 Å), and Polystyrene
-
Numerous other ligands are available upon customer’s request
-
Scientific publications** on the design, synthesis of non-nucleosidic solid supports and preparation of ligand-oligonucleotides conjugates
** 1. Guzaev, A. P. Oral presentation delivered at XXII International Round Table, Paris, July 2016
2. Gogoi, K., Vvedensky, V., and Guzaev, A.P. Poster presented at TIDES 2017 Conference, San Diego, May 2017 (PDF)