Non-nucleosidic Modifier Solid Supports
for Introducing Functional and Reporter Groups
Non-nucleosidic Solid Support
TFA Amino
CAS #: 2172952-52-0
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612201 | CPG 500 | $105 | 50 umol/g |
612202 | CPG 1000 | $105 | 40 umol/g |
612203 | Polystyrene | $105 | 100 umol/g |
612204 | CPG 1400 | $105 | 35 umol/g |
612205 | CPG 2000 | $105 | 30 umol/g * |
612206 | CPG 3000 | $105 | 25 umol/g * |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
*Max loading as allowed by the available surface area
Non-nucleosidic Solid Support
Alkyne
CAS #: 2172953-16-9
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612401 | CPG 500 | $105 | 50 umol/g |
612402 | CPG 1000 | $105 | 40 umol/g |
612403 | Polystyrene | $105 | 100 umol/g |
612404 | CPG 1400 | $105 | 35 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
Non-nucleosidic Solid Support
Fluorescein
CAS #: 2172953-45-4
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612501 | CPG 500 | $250 | 50 umol/g |
612502 | CPG 1000 | $250 | 40 umol/g |
612503 | Polystyrene | $250 | 100 umol/g |
612504 | CPG 1400 | $250 | 35 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
Non-nucleosidic Solid Support
Biotin
CAS #: 2172953-77-2
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612601 | CPG 500 | $325 | 50 umol/g |
612602 | CPG 1000 | $325 | 40 umol/g |
612603 | Polystyrene | $325 | 100 umol/g |
612604 | CPG 1400 | $325 | 35 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
Non-nucleosidic Solid Support
Pyrene
CAS #: 2172953-20-5
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612701 | CPG 500 | $210 | 50 umol/g |
612702 | CPG 1000 | $210 | 40 umol/g |
612703 | Polystyrene | $210 | 100 umol/g |
612704 | CPG 1400 | $210 | 35 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
Non-nucleosidic Solid Support
Dabsyl
CAS #: 2172953-53-4
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612801 | CPG 500 | $230 | 50 umol/g |
612802 | CPG 1000 | $230 | 40 umol/g |
612803 | Polystyrene | $230 | 100 umol/g |
612804 | CPG 1400 | $230 | 35 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
Non-nucleosidic Solid Support
Dabcyl
CAS #: 2172953-41-0
TMT denotes the trimethoxytrityl protecting group
p/n | Solid Phase Material | Price, $/g | Max Loading |
|---|---|---|---|
612901 | CPG 500 | $230 | 50 umol/g |
612902 | CPG 1000 | $230 | 40 umol/g |
612903 | Polystyrene | $230 | 100 umol/g |
612904 | CPG 1400 | $230 | 35 umol/g |
Please specify your desired loading with a span of 5 umol/g (i.e. 30-35 umol/g)
Product Details
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US Patent 10,781,175
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Minimum order size (25 g)
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For price info on package size of above 100 g for all p/n, please inquire (info@amchemicals.com)
Product Features
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Novel, achiral non-nucleosidic building blocks (TMT-protected)
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Amenable for single or multi-labeled oligo synthesis
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Incorporation of the phosphoramidites at terminal or any desired position of the oligonucleotide
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Compatible with standard oligonucleotide synthesis protocols
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Free of structural motifs that lead to undesired side reactions at the deprotection step
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Requires no special treatments or reaction conditions
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Synthetically feasible for scale-up and manufacturing
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Synthesis of DNA oligos with P=O and P=S backbones
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Synthesis of RNA oligos with P=O and P=S backbones
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Numerous phosphoramidites and solid supports:
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Solid phase material – CPG (500 Å, 1000 Å, or 1400 Å), and Polystyrene
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Numerous other ligands are available upon customer’s request
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Scientific publications** on the design, synthesis of non-nucleosidic solid supports and preparation of ligand-oligonucleotides conjugates
** 1. Guzaev, A. P. Oral presentation delivered at XXII International Round Table, Paris, July 2016
2. Gogoi, K., Vvedensky, V., and Guzaev, A.P. Poster presented at TIDES 2017 Conference, San Diego, May 2017 (PDF)