AM Chemicals, LLC, a supplier of solid supports and reagents for oligonucleotide and organic synthesis on solid phase

Convertible Solid Supports for 3'-Modification of Oligonucleotides

Convertible solid supports utilize the exceptional selectivity of the thioester function towards primary amines
and are used for the introduction of ligands and functional groups at the 3'-terminus of synthetic
oligonucleotides. Examples of the successful derivatization include 3'- aminoalkyl, mercaptoalkyl, aldehydo,
hydrazido, carboxy, imidazole, TEMPO, PROXYL, and lipophylic alkyl groups. Our experience with these solid
supports exceeds 10 years, which allowed us to develop a set of very reliable and user-friendly protocols
available in pdf format.

For ordering information, please consult the Table below.

To read and download the Guidelines for the use of Convertible Solid Supports (pdf format), please follow this
link.